Publications

17. Drown, B.S.; Gupta, R.; McGee, J.P.; Hollas, M.A.R.; Hergenrother, P.J.; Kafader, J.O.; Kelleher, N.L. "Precise Readout of MEK1 Proteoforms upon MAPK Pathway Modulation by Individual Ion Mass Spectrometry" Anal. Chem. 2024, 96, 4455-4462.
16. Anmangandla, A.; Jana, S.; Peng, K.; Wallace, S.D.; Bagde, S.R.; Drown, B.S.; Xu, J.; Hergenrother, P.J.; Fromme, C.; Lin, H. "A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain" ACS Chem. Biol. 2023, 18, 1200-1207.
15. Patel, R.; Terón, K. N.; Zhou, M.; Nakayasu, E.; Drown, B.S.; Das, C. "Genetically encoded crosslinking enables identification of multivalent ubiquitin-deubiquitylating enzyme interactions" ChemBioChem 2023, e202300305.
14. Campbell, T. L.; Drown, B. S. "Proteoforms feel the heat" Nat. Chem. Biol. 2023, doi:10.1038/s41589-023-01285-7.
13. Adams, L. M.; DeHart, C. J.; Drown, B. S.; Anderson, L. C.; Bocik, W.; Boja, E. S.; Hiltke, T. M.; Hendrickson, C. L.; Rodriguez, H.; Caldwell, M.; Vafabakhsh, R.; Kelleher, N. L. "Mapping the KRAS Proteoform Landscape in Colorectal Cancer Identifies Truncated KRAS4B That Decreases MAPK Signaling" J. Biol. Chem. 2023, 299, 102768.
12. Su, P., McGee, J. P., Durbin, K. R., Hollas, M. A. R., Yang, M., Neumann, E. K., Allen, J. L., Drown, B. S., Butun, F. A., Greer, J. B., Early, B. P., Fellers, R. T., Spraggins, J. M., Laskin, J., Camarillo, J. M., Kafader, J. O., Kelleher, N. L. "Highly multiplexed, label-free proteoform imaging oftissues by individual ion mass spectrometry" Sci. Adv. 2022, 8, eabp9929.
11. Drown, B. S., Jooß, K., Melani, R.D., Lloyd-Jones, C., Camarillo, J.M. and Kelleher, N.L. "Mapping the Proteoform Landscape of Five Human Tissues" J. Proteome Res. 2022, 21, 1299-1310.
10. Melani, R.D., Des Soye, B.J., Kafader, J.O., Forte, E., Hollas, M., Blagojevic, V., Negrão, F., McGee, J.P., Drown, B. S., Lloyd-Jones, C., Seckler, H.S., Camarillo, J.M., Compton, P.D., LeDuc, R.D., Early, B., Fellers, R.T., Cho, B.-K., Mattamana, B.B., Goo, Y.A., Thomas, P.M., Ash, M.K., Bhimalli, P.P., Al-Harthi, L., Sha, B.E., Schneider, J.R. and Kelleher, N.L. "Next-Generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire" J. Proteome Res. 2022, 21, 274-288.
9. Perlmutter, S.J., Geddes, E. J., Drown, B. S., Motika, S.E., Lee, M.R. and Hergenrother, P. J. "Compound Uptake into E. coli Can Be Facilitated by N-Alkyl Guanidiniums and Pyridiniums" ACS Infect. Dis. 2021, 7, 162-173.
8. Parker, E.N.,* Drown, B.S.,* Geddes, E.J., Lee, H.-Y., Ismail, N., Lau, G.W. and Hergenrother, P.J. "Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens" Nat. Microbiol. 2020, 5, 67-75.
7. Drown, B.S., Shirai, T., Rack, J.G.M., Ahel, I., Hergenrother, P.J. "Monitoring Poly(ADP-ribosyl)glycohydrolase Activity with a Continuous Fluorescent Substrate" Cell Chem. Biol. 2018, 25, 1562-1570.
6. Rack, J.G.M., Ariza, A., Drown, B.S., Henfrey, C., Shirai, T., Hergenrother, P.J., Ahel, I. "ADP-ribosyl Hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition" Cell Chem. Biol. 2018, 25, 1533-1546.
5. Drown, B.S., Hergenrother, P.J. "Going on offense against the gram-negative defense" Proc. Natl. Acad. Sci. U.S.A. 2018, 115, 6530-6532.
4. Richter, M.F., Drown, B.S., Riley, A.P., Garcia, A., Shirai, T., Svec, R.L., Hergenrother, P.J. "Predictive compound accumulation rules yield a broad-spectrum antibiotic" Nature 2017, 545, 299.
3. Garcia, A., Drown, B.S., Hergenrother, P.J. "Access to a structurally complex compound collection via ring distortion of the alkaloid sinomenine" Organic Letters 2016, 18, 4852.
2. Pederson, E.D., Barbalas, J., Drown, B.S., Culbertson, M., Burden, L.K., Kasianowicz, J.J., Burden, D.L. "Proximal capture dynamics for a single biological nanopore sensor" Journal of Physical Chemistry B 2015, 119, 10448.
1. Reiner, J.E., Balijepalli, A., Robertson, J.W.F., Drown, B.S., Burden, D.L., Kasianowicz, J.J. "The effects of diffusion on an exonuclease/nanopore-based DNA sequencing engine" Proc. Natl. Acad. Sci. U.S.A. 2012, 137, 214903.